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Size and performance in G.I. diagnostics.

The new ZepHr™ impedance/pH recorder is about one-third the size and weight of Sleuth™, but still incorporates all of the same outstanding characteristics that have made Sleuth™ the leading reflux recorder in the world. The ZepHr system employes impedance to detect reflux activity and uses pH to categorize each episode as acid or nonacid.

We call this unprecedented breakthrough Total Reflux Monitoring, because it delivers all the information you need for a precise, accurate assessment of acid and nonacid reflux as well as the correlation between reflux and symptoms.

All the data you need for precise, accurate assessment

Patients presenting with symptoms such as cough, heartburn, regurgitation and chest pain often are difficult to diagnose using traditional acid (pH) monitoring approaches.

Combining impedance and pH, ZepHr enables you to reliably distinguish between patients with acid reflux association, nonacid reflux association and symptoms with no reflux association.

Comprehensive analysis quantifies all reflux patterns and symptom associations in patients studied on or off acid suppression medication.

Indications for combined impedance/pH testing

· Persistent symptoms while on acid suppressive therapy
· Primarily postprandial symptoms
· Reflux symptoms and frequent meal ingestion (i.e., infants)

Treatment Conclusions

Patients with nonacid reflux identified by impedance/pH whose symptoms have not responded to PPI therapy may benefit from the use of other medications.¹
Positive symptom index for nonacid or acid reflux using impedance/pH predicts successful response to Laparoscopic Nissen Fundoplication.²
Clinical trials have established that nonacid reflux can be associated with GERD symptoms. In addition, ZepHr provides a true negative study by identifying patients with no reflux association.²

Featuring BioVIEW^® G.I. Diagnostic Software

Powered by Sandhill's world-renowned BioVIEW^® analysis software (with the revolutionary AutoSCAN^® feature), reports are generated simply and quickly, making reflux monitoring no longer a mystery. AutoSCAN* takes the guesswork out of interpreting a 24 hour impedance/pH study.

Plus, BioVIEW allows you to perform a Z Swallow Challenge™ bolus transit screening test during an impedance/pH test with a single intubation. The test can be viewed and analyzed when the impedance/pH study is completed. Only this ZepHr/BioVIEW combination provides a simple and effective tool to identify patients with bolus transit impairment concurrently with acid and nonacid reflux monitoring.

ContourVIEW™
(Uses easy to understand color plots to view reflux episodes)

RapidVIEW™
(Quick visualiza-
tion of an acid or nonacid reflux event)

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* patent pending
1. Agrawal and Castell; Reflux Reduction Therapy: When PPI's Are Not Enough, Practical Gastroenterology, 68-72, April 2006.
2. Inder Mainie, R. Tutuian & D. O. Castell; Medical University of South Carolina; Symptoms on PPI Therapy Associated with Nonacid, Acid or No Reflux; ACG Presentation; October 2004.
3. Patients with typical symptoms (heartburn, regurgitation, chest pain) while on PPI Therapy.